Olink Explorer >5400

Requirements:

2.0       BACKGROUND 

Our lab studies the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression and therapy of cancer. 

The following product features/characteristics are required for this requirement:  

Protein Coverage - Measures ~5,400+ human proteins simultaneously in a single workflow. 

Technology - Uses Proximity Extension Assay (PEA) with dual antibody recognition coupled to DNA barcoding and next-generation sequencing (NGS) readout. 

Sample input – requires only 2 ul of plasma, serum, and other sample types 

Specificity - Reported 99.5% specificity with negligible cross-reactivity due to dual-recognition antibody design. 

Dynamic Range - Approximately 10 orders of magnitude (fg/mL to mg/mL), enabling detection of both low- and high-abundance proteins. 

Key strengths 

• Very broad proteome coverage while maintaining antibody-based specificity.  

• Excellent sensitivity for low-abundance circulating proteins (especially cytokines and signaling proteins).  

• Extremely low sample-volume requirement.  

• Highly standardized platform, making it attractive for epidemiology and multi-omics studies.