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Notice ID: 8d7bb66b691a4def9e7efe4d4345bb7aSolicitation

Protein ENGineering (PENG)

Responses closed . Full description on SAM.gov.

Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline.

The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Full description on SAM.gov

Overview

Agency:
Department of WarDEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office:DEF ADVANCED RESEARCH PROJECTS AGCY
Posted:August 21, 2026
NAICS:541714: Research and Development in Biotechnology (except Nanobiotechnology)
Last Updated:Oct 22, 2026
First published:
Last updated on SAM.gov:
PSC:AC12: NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; APPLIED RESEARCH
Set-Aside:Not specified
Type:Solicitation
Place of Performance:Not specified

Award Overview

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Contacts

Contracting Officer

Primary Contact

BAA Coordinator
PENG@darpa.mil

Documents

Files (13)

  • DARPA-PS-26-129-Amendment-01.pdf

    400 KBAdded in Solicitation version 2Posted
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  • Attachment_D_Proposal_Inst_and_Vol_I_Template_Tech_and_Management_Amendment_1.docx

    56 KBAdded in Solicitation version 2Posted
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  • PENG_Amendment_1_Summary_of_Changes.docx

    26 KBAdded in Solicitation version 2Posted
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  • DARPA-PS-26-129.pdf

    365 KBAdded in Solicitation version 1Posted
    Download

  • Attachment_I_Schedule_of_Milestones_and_Payments.xlsx

    22 KBAdded in Solicitation version 1Posted
    Download

  • Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docx

    46 KBAdded in Solicitation version 1Posted
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  • Attachment_H_Task_Description_Document__TDD_.docx

    37 KBAdded in Solicitation version 1Posted
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  • Attachment_G_Model_Other_Transaction_for_Prototype.docx

    94 KBAdded in Solicitation version 1Posted
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  • Attachment_F_DARPA_Cost_Proposal_Spreadsheet.xlsx

    129 KBAdded in Solicitation version 1Posted
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  • Attachment_D_Proposal_Instructions_and_Volume_I_Template_Technical_and_Management.docx

    56 KBAdded in Solicitation version 1Posted
    Download

  • Attachment_C_Proposal_Summary_Slide_Template.pptx

    135 KBAdded in Solicitation version 1Posted
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  • Attachment_B_Abstract_Instructions_and_Template.docx

    43 KBAdded in Solicitation version 1Posted
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  • Attachment_A_Abstract_Summary_Side.pptx

    425 KBAdded in Solicitation version 1Posted
    Download

Lifecycle

  1. 1
    Version 1Solicitation

    Protein ENGineering (PENG)

    Notice be313c6423e841ae9572a0878b3d9bbb on SAM.gov

  2. 2
    Version 2SolicitationCurrent

    Protein ENGineering (PENG)

    Notice 8d7bb66b691a4def9e7efe4d4345bb7a on SAM.gov

Similar Opportunities

Title
Phase
Agency
NAICS
Set Aside
Posted
Deadline
Location

Additional Details

Solicitation Number

DARPA-PS-26-129

Archive Date

Nov 18, 2026

Office Address

ARLINGTON, VA, 222032114

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