Notice ID: fdfe0e2c0a074033b7238802e3d87d14Solicitation
Protean
Archived on June 6, 2026. Original response deadline: . Full description on SAM.gov.
Description
This Research Announcement represents a solicitation for a research thrust, entitled Protean, that will focus on identifying novel ways to restore protein function to targets of chemical threat agents.
Overview
Agency:
Department of WarDEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office:DEF ADVANCED RESEARCH PROJECTS AGCY
Posted:March 11, 2026
NAICS:541714: Research and Development in Biotechnology (except Nanobiotechnology)
Last Updated:Aug 21, 2026
PSC:AC12: NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; APPLIED RESEARCH
Set-Aside:Not specified
Type:Solicitation
Place of Performance:Not specified
Award Overview
Possible prior contracts
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Contacts
Contracting Officer
Primary Contact
BAA Coordinator
Documents
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Showing 6 of 6 items
Document | Source | Agency | Posted Date | File Size | Actions | |
|---|---|---|---|---|---|---|
| Solicitation | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) | Mar 11, 2026 | 48.27 KB | |||
| Solicitation | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) | Mar 11, 2026 | 85.13 KB | |||
| Solicitation | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) | Mar 11, 2026 | 312 KB | |||
Attachment_1_-_PROPOSAL_TEMPLATE_-_VIDEO_ABSTRACTS.pptx | Solicitation | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) | Mar 11, 2026 | 30.55 MB | ||
| Solicitation | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) | Mar 11, 2026 | 646.13 KB | |||
| Solicitation | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) | Mar 11, 2026 | 93.9 KB |
Lifecycle
Solicitation:
DARPARA2601- Solicitation
Award typically follows within 30–90 days after the response deadline. (estimate)
- 2×
Similar Opportunities
Title | Phase | Agency | NAICS | Set Aside | Posted | Deadline | Location |
|---|---|---|---|---|---|---|---|
The Ice Control for cold Environments (ICE) program BAA was solicited on August 15, 2022, for the purpose of seeking to develop solutions for extreme cold weather DoW operational challenges by discovering and optimizing biologically sourced or inspired molecules to enable tuned inhibition or nucleation of ice crystallization, propagation, and adhesion. The ICE BAA was solicited for Phase I and Phase II with a notional Phase III that was to be solicited at a later date. This justification provides the rationale for awarding a sole-source modification to the current Phase II contractor, to continue this work into Phase III under the authority of FAR 6.302-1, "Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements." | Sole Source / J&A | 541714 | No Set-Aside | 10/16/2026 | Open | Boston, MA | |
THIS NOTICE IS NOT A REQUEST FOR PROPOSALS OR A COMPETITIVE SOLICITATION. The Defense Advanced Research Projects Agency (DARPA) intends to enter into an Agreement with The University of Texas System consortium of universities in support of the Biological Technologies Office (BTO) LiveChain Program for an integrated research initiative focused on autonomous medical care, casualty evacuation, clinical decision support, and resilient medical supplies in austere and contested environments. | Special Notice | 541714 | No Set-Aside | 10/16/2026 | 11/15/2026 | - | |
The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury. | Solicitation | 541714 | No Set-Aside | 10/08/2026 | 11/05/2026 | - | |
The Defense Advanced Research Projects Agency (DARPA) has developed a non-invasive coherent optical system capable of recording neural signals in humans. To expand this foundational technology and enable the development of revolutionary, non-invasive brain-computer interfaces (BCIs), DARPA's Firefox program is soliciting approaches to overcome key technological hurdles: 1) development of components enabling dynamic rastering/scanning of the incoming coherent optical signal to target multiple regions of interest and 2) development of new data processing architectures beyond the digital domain to handle the high data rates and computational burden inherent to scaling the amount of neural data recorded by the optical system. The ultimate goal of the Firefox program is to use these innovations to develop a 100-channel, non-invasive BCI with 50-micron spatial and 100-microsecond temporal resolution. | Solicitation | 541714 | No Set-Aside | 09/16/2026 | 11/09/2026 | - | |
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level. | Solicitation | 541714 | No Set-Aside | 08/21/2026 | 10/19/2026 | - |
Additional Details
Solicitation Number
DARPARA2601
Archive Date
Jun 6, 2026
Office Address
ARLINGTON, VA, 222032114